Mitochondrial Inhibitors and Neurodegenerative Disorders (Contemporary Neuroscience) pdf epub fb2

Mitochondrial Inhibitors and Neurodegenerative Disorders (Contemporary Neuroscience) by - pdf epub fb2

Mitochondrial Inhibitors and Neurodegenerative Disorders (Contemporary Neuroscience) Author: -
Title: Mitochondrial Inhibitors and Neurodegenerative Disorders (Contemporary Neuroscience)
ISBN: 089603805X
ISBN13: 978-0896038059
Other Formats: txt doc mobi azw
Pages: 314 pages
Publisher: Humana Press; 2000 edition (October 1, 1999)
Language: English
Category: Medical Books
Size PDF version: 1427 kb
Size EPUB version: 1273 kb
Subcategory: Medicine




Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito­ chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mitochondrial electron transport system. Consistent with their ancestry, the mitochondria have their own DNA that encodes many but not all of their proteins. The mitochon­ dria and their genes come from the mother via the ovum since sperm do not possess mitochondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mitochondrial gene mutations might be a source of human dis­ ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.