The ADAM Family of Proteases (Proteases in Biology and Disease) pdf epub fb2

The ADAM Family of Proteases (Proteases in Biology and Disease) by Nigel M Hooper, Uwe Lendeckel pdf epub fb2

The ADAM Family of Proteases (Proteases in Biology and Disease) Author: Nigel M Hooper, Uwe Lendeckel
Title: The ADAM Family of Proteases (Proteases in Biology and Disease)
ISBN: 0387251499
ISBN13: 978-0387251493
Other Formats: mbr txt mobi doc
Pages: 344 pages
Publisher: Springer; 2005 edition (June 23, 2005)
Language: English
Category: Medical Books
Size PDF version: 1379 kb
Size EPUB version: 1708 kb
Subcategory: Medicine




The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.